My brother and I have a genetic condition called hemochromatosis. Our original testing determined that we both inherited one bad gene from each of our parents, but we didn’t know until recent further testing that I actually received four bad genes (I am homozygous for both major hemochromatosis alleles). My parents were both carriers for hemochromatosis at two separate genes and I got both of the bad genes (it’s a 1 in 16 chance) from each of my parents. It was through “23andme” that I was able to obtain this information, and I want to recommend it to you.
The FDA recently took away the ability of 23andme and all
other genetic sequencing companies to send health reports to their clients.
However, we can still use the “raw data” available on the 23andme website to do
our own investigating. Clicking on “browse raw data” you can see which version
(allele or SNP) of each gene you have. You can then look up your version on
snpedia.com to find out more about the health and trait characteristics of your
version of the gene. This process is time consuming because you must do it one
gene at a time, but I found another reputable company that will do this rapidly
and automatically using the 23andme data.
http://www.promethease.com
Promethease Inc. is a popular service that will create a
report for 17,000 of our 23,000 genes for only $5. You can obtain this
additional service from promethease.com. You actually allow promethease.com to
access the 23andme data by signing in to both at the same time. The whole
process and the reports are pretty straightforward, but you definitely want to
download the data to your computer because Promethease wipes their servers
every month. Promethease is reputed to be a very legitimate company and the reports
that it provides seem to be more detailed than the other companies that do the
same thing. Check out this article on Promethease from MIT’s technology review:
http://www.technologyreview.com/featuredstory/531461/how-a-wiki-is-keeping-direct-to-consumer-genetics-alive
I think it is worth the time and the $5 to use this
additional service. The health report that they send gives you all of your
genetic risk factors ranked from a magnitude of 1 to 4. I think it is important
for everyone to see if they have any 4s, and to inform their health care
providers about what they have learned. Again, I found out that I have more
than one gene that predisposes me to hemochromatosis (both have a ranking of
4), and this has definitely changed my treatment plan. We also found out that
we have genetic propensity for rheumatoid arthritis, and that my mother and
brother have a problem metabolizing anti-inflammatory drugs (NSAIDs). Again
knowing this is important because now they know to take Tylenol rather than
aspirin or Advil.
So far, a number of my friends and family members have done
both 23andme and promethease. It is really fun to compare and contrast profiles
because it gives you a much better understanding of your own data.
This was a good suggestion that you put up here.hope that it benefits all the ones who land up here.
ReplyDeletepromethus dna
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23andme raw data
choline deficiency
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